品牌:美國 NewEast Biosciences
貨號(hào): 26912
抗原:Full Recombinant Active Rap1
規(guī)格:30 微升
產(chǎn)品全名:Anti-Rap1-GTP Monoclonal Antibody
應(yīng)用: IP, IHC, IF
種屬反應(yīng)性的選擇:Human, Mouse and Rat
物種/宿主:Mouse
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基因符號(hào): RAP1
描述: Anti-Rap1-GTP Mouse Monoclonal Antibody
背景介紹: Small GTPases are a super-family of cellular signaling regulators. Rap family members (Rap1A, Rap1B, Rap2A, Rap2B, and Rap2C) are Ras-like GTPases that regulate cell proliferation, differentiation, apoptosis and adhesion mechanisms. Rap1 (Ras-proximate-1) regulates apoptosis through interaction with two MAP3K effectors of the MEK/ERK MAP-kinase pathway, Raf-1 and B-Raf. Rap1 regulates cell adhesion mechanisms through effector molecules such as the integrins and cadherins.
免疫原: Recombinant full length protein of active Rap1.
經(jīng)過測試的應(yīng)用: IP, IHC, IF
推薦稀釋比: IP: 1 μg for 1~2 mg total cellular proteins IHC, IF: 1:50-1:250
濃度: 1 mg/ml
宿主: Mouse
形式: Liquid
克隆性: Monoclonal
亞型: IgG
純度: Purified from ascites
防腐劑: No
成分: PBS (without Mg2+and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
種屬反應(yīng)性: Anti-Rap1-GTP monoclonal antibody recognizes active Rap1 of vertebrates.
儲(chǔ)存條件: Store at -20°C. Avoid repeated freezing and thawing
免疫沉淀/蛋白質(zhì)印跡:
Rap1 Activation Assay.Purified Rap1 proteins were immunoprecipitated after treated with GDP (lane 1) or GTPγS (lane 2). Immunoprecipitation was done with the anti-Rap1-GTP monoclonal antibody (Cat. No. 26912). Immunoblot was with an anti-Rap1 polyclonal antibody (Cat. No. 21104).
武漢費(fèi)斯德生物科技有限公司是美國NewEast Biosciences在中國的辦事處，也是目前r所有產(chǎn)品國內(nèi)經(jīng)銷處。
目前客戶使用產(chǎn)品發(fā)表超過1000谷歌學(xué)術(shù)文獻(xiàn)，其中論文分布排名前50刊物上。
NewEast Biosciences 在十二年前率先研發(fā)倆種獨(dú)特的抗體。這倆種抗體僅僅識(shí)別活性的GTP酶或者突變的Oncogene。 GTP酶涉及(1)響應(yīng)細(xì)胞表面受體**的信號(hào)轉(zhuǎn)導(dǎo)，包括跨膜受體，例如介導(dǎo)味覺、嗅覺和視覺的那些，（2）核糖體的蛋白質(zhì)生物合成，（3）調(diào)節(jié)細(xì)胞分化、增殖、分裂和運(yùn)動(dòng)，（4）蛋白質(zhì)通過膜的易位，（5）細(xì)胞內(nèi)囊泡的運(yùn)輸，以及囊泡介導(dǎo)的分泌和攝取，通過GTP酶控制囊泡外殼組裝。Oncogene側(cè)是誘發(fā)癌癥的基因。
更多產(chǎn)品類目和技術(shù)資料可查看：武漢費(fèi)斯德生物官網(wǎng)。
