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CalcuSyn是目前市場上運用極為廣泛的混合藥物分析軟件，該軟件可以自動量化各種藥物作用過程，比如：協(xié)同作用和抑制作用等。目前在臨床醫(yī)學(xué)上混合藥物正逐漸廣泛運用于癌癥、艾滋病等疾病的治療。它具有多種藥物的劑量效應(yīng)計算，數(shù)據(jù)可處理兩個單獨藥品、恒定的比例或非恒定比率的組合。CalcuSyn采集的數(shù)據(jù)可以直接通過鍵盤或者導(dǎo)入文件形式輸入到系統(tǒng)中或者直接進(jìn)入分析引擎中。處理的數(shù)據(jù)既可以是單一藥物的也可以是混合藥物的恒定比率或非恒定比率。同時根據(jù)數(shù)據(jù)自動繪圖，并能得到所有藥物和藥物相互作用的詳細(xì)分析報告，包括組合指數(shù)和能譜分析。該軟件能打印各種結(jié)果和圖表，能導(dǎo)出到電子表格、Word進(jìn)行進(jìn)一步處理中等。軟件含PDF的介紹手冊和幫助功能。該軟件已經(jīng)被數(shù)國內(nèi)外很多實驗室和制藥公司廣泛應(yīng)用，成為混合藥物研究中必不可少的工具。
單藥和多藥的劑量-效應(yīng)分析儀
CalcuSyn2.0版是組合藥物效應(yīng)的權(quán)威分析儀，能夠自動量化協(xié)同作用和抑制等現(xiàn)象?；旌纤幬镏委熢诎┌Y，艾滋病等的治療中變得越來越普遍，而CalcuSyn用于在該領(lǐng)域建立療效的廣泛使用的軟件。它使用TCChou和P.Talaly（TrendsPharmacol.Sci.4,450-454）描述中位效應(yīng)方法進(jìn)行多種藥物劑量效應(yīng)計算。
CalcuSyn可以輕松地與其他軟件集成?？梢酝ㄟ^鍵盤或文件導(dǎo)入數(shù)據(jù)輸入網(wǎng)格或直接輸入分析引擎。使用網(wǎng)格時，可以通過向?qū)幚頂?shù)據(jù)，使新用戶可以輕松訪問該軟件。
可以針對單個藥物和恒定比例或非恒定比例的藥物組合處理數(shù)據(jù)。CalcuSyn自動繪制數(shù)據(jù)圖并生成報告，提供所有藥物的匯總統(tǒng)計數(shù)據(jù)以及藥物相互作用的詳細(xì)分析，包括組合指數(shù)和EDx（對于x的任何值）?？梢允褂妹商乜_模擬或高精度代數(shù)估計算法計算EDx和CI的準(zhǔn)確度估計值。CalcuSyn繪制的圖包括劑量效應(yīng)，中值效應(yīng)，等效線圖和CI效應(yīng)。
CalcuSyn2.0版具有撤銷和重做工具?？伸`活安排打印結(jié)果和圖表，并將其導(dǎo)出到電子表格，文字處理程序，圖形軟件包等。一本綜合手冊以軟件形式提供.pdf，并有詳細(xì)的幫助文件。這些分析方法的理論基礎(chǔ)，包括結(jié)果的統(tǒng)計處理。CalcuSyn已經(jīng)在數(shù)百家學(xué)術(shù)實驗室和制藥公司中使用，對于藥物混合物的研究是不可或缺的。
CalcuSyn主要特點
CalcuSyn是目前市場上運用非常廣泛的混合藥物分析軟件
該軟件可以自動量化各種藥物作用過程，比如：協(xié)同作用和抑制作用等
具有多種藥物的劑量效應(yīng)計算，數(shù)據(jù)可處理兩個單獨藥品、恒定的比例或非恒定比率的組合
CalcuSyn采集的數(shù)據(jù)可以直接通過鍵盤或者導(dǎo)入文件形式輸入到系統(tǒng)中或者直接輸入分析引擎中
處理數(shù)據(jù)既可以是單一藥物的也可以是混合藥物的恒定比率或非恒定比率
同時根據(jù)數(shù)據(jù)自動繪圖，并能得到所有藥物和藥物相互作用的詳細(xì)分析報告，包括組合指數(shù)和能譜分析
該軟件能打印各種結(jié)果和圖表，能夠?qū)С鲭娮颖砀瘛ord進(jìn)行進(jìn)一步處理中等
軟件含PDF的介紹手冊和幫助功能。該軟件已經(jīng)被數(shù)國內(nèi)外很多實驗室和制藥公司廣泛應(yīng)用，成為混合要唔要就中必不可少的工具
【英文介紹】
CalcuSyn Version 2.0 is the definitive analyzer of combined drug effects, able automatically to quantify phenomena such as synergism and inhibition. Mixed drug treatment is becoming common in the treatment of cancer, AIDS etc, and CalcuSyn is the most widely used software for establishing efficacy in this field. It performs multiple drug dose-effect calculations using the Median Effect methods described by T-C Chou and P. Talalay (Trends Pharmacol. Sci. 4, 450-454).
CalcuSyn can easily be integrated with other software. Data can be entered via the keyboard or file import either into the grid or directly into the analysis engine. When the grid is used, data can be processed through wizards which make the software easily accessible to new users.
Data can be processed both for individual drugs and for constant-ratio or non-constant-ratio combinations of drugs. CalcuSyn automatically graphs the data and produces reports giving summary statistics on all drugs plus detailed analysis of drug interactions including the Combination Index and EDx (for any value of x). Estimates of accuracy of EDx and CI can be calculated with Monte Carlo simulations or by a highly accurate algebraic estimation algorithm. The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect. All data and results are easily accessible by mouse-click on the contents tree.
CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, graphics packages etc. A comprehensive manual is supplied as .pdf with the software and there is a detailed Help file. These give a thorough account of the theoretical basis of the analysis methods including the statistical treatment of results. Already used in hundreds of academic labs and pharmaceutical companies, CalcuSyn is indispensable for the study of drug mixtures.
General Science Range（普通的科學(xué)范圍）
FigSys- Publication quality graph plotting and data analysis.
Stat-200- General statistics and graphics package.
UnGraph- Digitizer program which gives X,Y coordinates of lines or points on scanned images.
Biomedical Range（生物醫(yī)學(xué)范圍）
AssayZap- Universal assay calculator for RIA, ELISA, IRMA, colorimetric or any other type of assay.
CalcuSyn- Dose-effect analysis.
EnzFitter- Curve fitting and analysis of enzyme kinetics experiments.
QuantiScan- Densitometry using ordinary office scanners.
Educational / Teaching Range（教育/教學(xué)范圍）
NeuroSim- Neurophysiology simulations.
CardioLab- Simulation of in vivo cardiovascular pharmacology experiments.
Ileum- Simulation of experiments on the isolated Guinea-pig Ileum.
